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• 产品描述：

  Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)

  产品溶液形式不稳定，建议现配现用。开封后保存请加封口膜和密封袋在干燥处保存。

• 靶点： Ferroptosis;VDAC

• 体内研究：
  Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice

• 参考文献：
  1. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. 2. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79. 3. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.

• 溶解性： DMSO  :  12.5  mg/mL  (22.85  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (insoluble)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.828 ml	9.14 ml	18.28 ml
  5 mM	0.366 ml	1.828 ml	3.656 ml
  10 mM	0.183 ml	0.914 ml	1.828 ml
  50 mM	0.037 ml	0.183 ml	0.366 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 10. [4] Yinhao ZHANG et al."Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis."Chinese Journal of Natural Medicines.2024 Sep;22:769

• 9. [3.1] Jing Xin et al."Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2024 Aug;:1-11

• 8. [5.8] Muran Jiang et al."Copper oxide nanoparticles induce cuproptosis and ferroptosis through mitochondrial concatenation."Environmental Science-Nano.2024 Jul;:

• 7. [5.3] Xue Xiaoyong et al."Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice."Chinese Medicine.2024 Dec;19(1):1-22

• 6. [IF=3.7] Xianqi Zhang et al."Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production."EXPERIMENTAL CELL RESEARCH".2024 May;438:114034

• 5. [IF=4.7] Sheng Hu et al."Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway."NEUROPHARMACOLOGY".2024 Jun;251:1

• 4. [IF=3.8] Zhang Yunwen et al."Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression."BMC CANCER.2023 Dec;23(1):1-15

• 3. [IF=3] Zhang Meixia et al."NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma."JOURNAL OF BIOENERGETICS AND BIOMEMBRANES.2023 Oct;:1-12

• 2. [4.831] Ying Lan et al."Polysiloxane-based hyperbranched fluorescent probe for dynamic visualization of HClO in lysosomes and vivo."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Jun;294:122527

• 1. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *