TG100-115

    
98%

TG100-115

源叶(MedMol)
S80889 一键复制产品信息
677297-51-7
C18H14N6O2
346.35
6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80889-1mg 98% ¥170.00 10 - - -
S80889-5mg 98% ¥595.00 6 - - -
S80889-10mg 98% ¥990.00 8 - - -
S80889-25mg 98% ¥1400.00 6 - - -
S80889-50mg 98% ¥2400.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively.

产品描述: TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively.
靶点: PI3Kδ:235 nM (IC50);PI3Kγ:83 nM (IC50);PI3K
体内研究: To correlate these in vivo responses with the molecular target of interest, PI3K pathway signaling is monitored through western blot analyses of Akt phosphorylation (a PI3K-mediated event). VEGF injection i.v. in mice induces a rapid Akt phosphorylation readily detectable in lung lysates, pretreatment with TG100-115 blocks this response. Blockade is seen with TG100-115 doses as low as 0.5 mg/kg and persists over a period of several hours. In initial dose-ranging studies, generally equivalent responses are observed using TG100-115 doses of 0.5-10 mg/kg, and we therefore elected to conduct a statistically powered test at the lowest dose. Animals dosed with TG100-115 as a single 0.5 mg/kg i.v. bolus 30 min after reperfusion developed smaller infarcts vs. vehicle-treated controls. Measuring infarct area as percent of total LV ischemic area, infarct size is reduced by 35% (P=0.04). Viable tissue within the ischemic zone is increased by 37% (P=0.04), directly demonstrating the cardioprotective effect of PI3Kγ/δ inhibition
参考文献: 1. Doukas J, et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.
溶解性: DMSO  :  33.33  mg/mL  (96.23  mM;  ultrasonic  and  warming  and  adjust  pH  to  2  with  HCl  and  heat  to  60°C)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.887 ml 14.436 ml 28.873 ml
5 mM 0.577 ml 2.887 ml 5.775 ml
10 mM 0.289 ml 1.444 ml 2.887 ml
50 mM 0.058 ml 0.289 ml 0.577 ml
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参考文献

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