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S80942

Solithromycin

源叶(MedMol) 99%
  • 英文名:
  • Solithromycin
  • 别名:
  • CAS号:
  • 760981-83-7
  • 分子式:
  • C43H65FN6O10
  • 分子量:
  • 845.0088
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80942-1mg 99% ¥230.00元 9 - - - EA 加入购物车
源叶(MedMol) S80942-5mg 99% ¥530.00元 >10 - - - EA 加入购物车
源叶(MedMol) S80942-25mg 99% ¥1496.00元 7 - - - EA 加入购物车
源叶(MedMol) S80942-100mg 99% ¥3400.00元 7 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC50s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis
  • 靶点: Macrolide;Antibacterial;Antibiotic
  • 体外研究:
    The IC50s values for Solithromycin on TNFα and CXCL8 release are 41.6 μM and 78.2 μM, respectively. Solithromycin markedly reduces MMP9 activity, with an IC50 of 14.9 μM. Solithromycin (0-333 μM; 72 hours; U937 and PBMC cells) suppresses lipopolysaccharide-induced TNFα release and phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase 9 (MMP9) activity, and does not affect cell viability in monocytic U937 and PBMC cells
  • 体内研究:
    Solithromycin (100 mg/kg; oral administration; every day; for 8 days; C57BL/6J mice) treatment inhibits inflammatory cells accumulation and pro-MMP9 production in cigarette smoke-exposed mice. Animal Model: C57BL/6J mice (male, 4 weeks) Dosage: 100 mg/kg Administration: Oral administration; every day; for 8 days Result: Inhibited cigarette smoke-induced neutrophilia and pro-MMP9 production.
  • 参考文献:
    1. Rodgers W, et al. Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus,Streptococcus pneumoniae, and Haemophilus influenzae. Antimicrob Agents Chemother. 2013 Apr;57(4):1632-1637. 2. Kobayashi Y, et al. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition. J Pharmacol Exp Ther. 2013 Apr;345(1):76-84.
  • 溶解性: Soluble  in  DMSO、H2O
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.183 ml 5.917 ml 11.834 ml
    5 mM 0.237 ml 1.183 ml 2.367 ml
    10 mM 0.118 ml 0.592 ml 1.183 ml
    50 mM 0.024 ml 0.118 ml 0.237 ml
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