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• 产品描述： Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).

• 靶点： Adrenergic Receptor;AdrenergicReceptor

• 体内研究：
  Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat.

• 参考文献：
  1.Palea S, et al. BJU Int,2003, 91(9), 873-877. 2.Lacerda AE, et al. J Pharmacol Exp Ther,2008, 324(2), 427-433. 3.Tambaro S, et al. J Pharmacol Exp Ther,2005, 312(2), 710-717. 4.Mayoux E, et al. Eur Urol,2004, 45(1), 110-116. 5.Lefèvre-Borg F, et al. Br J Pharmacol. 1993 Aug;109(4):1282-9.

• 溶解性： DMSO:10.7  mg/mL  (25  mM)    H2O:10.7  mg/mL  (25  mM)

• 保存条件： RT

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.348 ml	11.74 ml	23.479 ml
  5 mM	0.47 ml	2.348 ml	4.696 ml
  10 mM	0.235 ml	1.174 ml	2.348 ml
  50 mM	0.047 ml	0.235 ml	0.47 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *