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• 产品描述： NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer

• 靶点： IC50: 4 μM (LNCaP cells), 1.7 μM (Granta cells);Apoptosis;p53

• 体外研究：
  NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation. NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells. NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin. NSC348884 (1-5 μM; 24 h) induces cell apoptosis. NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53. Cell Viability Assay Cell Line: LNCaP and Granta cell lines Concentration: 0.01-100 μM Incubation Time: 4 days Result: Inhibited LNCaP cells and Granta cell lines with IC50s of 4 and 1.7 μM, respectively. Apoptosis Analysis Cell Line: LNCaP cell line Concentration: 1-5 μM Incubation Time: 24 h Result: Induced apoptosis in LNCaP cell line. Western Blot Analysis Cell Line: LNCaP cell line Concentration: 0-5 μM Incubation Time: 0-24 h Result: Dose-dependently increased both p53 protein level and phosphorylation on Ser15, and increased the concentration of p21. Western Blot Analysis Cell Line: SKOV3, ES2 and MOSEC/Luc cell lines Concentration: 0, 2.5 and 5 μM Incubation Time: 48 h Result: Increased PD-L1 expression in ovarian cancer cells.

• 体内研究：
  NSC348884 (50 μg; i.p. once) reduces tumor growth. Animal Model: C57Bl/6J mice with MOSEC/Luc cells injection Dosage: 50 μg Administration: Intraperitoneal injection; 50 μg once Result: Reduced tumorigenesis, but not completely inhibited.

• 参考文献：
  1. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20. 2. Lin Y, et al. Inhibition of nucleophosmin/B23 sensitizes ovarian cancer cells to antiprogrammed cell death protein-1 ligand therapy. 2022.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.57 ml	7.852 ml	15.704 ml
  5 mM	0.314 ml	1.57 ml	3.141 ml
  10 mM	0.157 ml	0.785 ml	1.57 ml
  50 mM	0.031 ml	0.157 ml	0.314 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *