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• 产品描述： GSK269962A (GSK 269962) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. GSK269962A has anti-inflammatory and vasodilatory activities

• 靶点： ROCK1:1.6 nM (IC50);ROCK2:4 nM (IC50);RSK1:132 nM (IC50);MSK1:49 nM (IC50);AKT1:955 nM (IC50);AKT2:1350 nM (IC50);AKT3:1510 nM (IC50);CDK2:3500 nM (IC50);GSK3α:1260 nM (IC50);ROCK;S6Kinase

• 体内研究：
  GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial

• 参考文献：
  1. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.753 ml	8.763 ml	17.525 ml
  5 mM	0.351 ml	1.753 ml	3.505 ml
  10 mM	0.175 ml	0.876 ml	1.753 ml
  50 mM	0.035 ml	0.175 ml	0.351 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *