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• 产品描述： ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research

• 靶点： Bcl-2:30.3 nM (EC50);Bcl-xL:78.7 nM (EC50);Bcl-W:197.8 nM (EC50);Bcl-B:1820 nM (EC50);Bfl-1:>10 μM (EC50);Mcl-1:>10 μM (EC50);Mitophagy; BCL; Autophagy

• 体内研究：
  ABT-737 (20, 30 mg/kg/day; i.p.; for 21 days) suppresses the leukemia burden by 48% and 53% at the 20 and 30 mg/kg dose levels, respectively, in four- to six-week-old CB.17 Scid mice with human leukemia KG-1 cells. ABT-737 significantly extends survival of mice in this aggressive leukemia model.

• 参考文献：
  1. Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88. 2. Ahamed Saleem, et al. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012 Sep 1;72(12):1374-81. 3. Clerc P, et al. Polster BM.Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry.PLoS One. 2012;7(8):e42487. Epub 2012 Aug 3.

• 溶解性： DMSO  :  50  mg/mL  (61.47  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.229 ml	6.147 ml	12.294 ml
  5 mM	0.246 ml	1.229 ml	2.459 ml
  10 mM	0.123 ml	0.615 ml	1.229 ml
  50 mM	0.025 ml	0.123 ml	0.246 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [6.9] Xiaoxue Lang et al."TPGS nanoparticles co-loaded with ABT-737 and R848 for breast cancer therapy."BIOMEDICINE & PHARMACOTHERAPY.2024 Aug;177:117107

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *