| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 南京 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81009-5mg一口价 |
98.70% | ￥384.00 ￥307.00 |
9 | - | - | - | - |
|
S81009-10mg一口价 |
98.70% | ￥600.00 ￥480.00 |
9 | - | - | - | - |
|
S81009-50mg |
98.70% | ￥1920.00 |
4 | - | - | - | - |
|
S81009-100mg |
≥98% | ￥3360.00 |
货期：2-3天 | - | - | - | - |
|
S81009-200mg |
≥98% | ￥5360.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM | ||||||||||||||||||||
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| 靶点： | EC50: 700 nM (TCF-dependent transcriptional activity);Wnt/beta-catenin | ||||||||||||||||||||
| 体外研究： | BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen. BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group. Western Blot Analysis Cell Line: Human gastric cancer cell lines MNK45 and AGS Concentration: 10 µM Incubation Time: 24 hours Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells. | ||||||||||||||||||||
| 体内研究： | BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos | ||||||||||||||||||||
| 参考文献： | 1. Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90. 2. Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb;19(2):817-824. 3. Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep;255:126889. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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