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- 产品描述： VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
- 靶点： ERK2:2 nM (Ki);GSK3:395 (Ki);CDK2:852 (Ki);AURA:540 (Ki)
- 体内研究：
VX-11e is orally bioavailable in both rat and mice. VX-11e (50 mg/kg, p.o.) results in robust inhibition of pRSK, and inhibits tumor growth in NSG mice bearing human melanoma RPDX tumors. VX-11e with BKM120 significantly improves tumor growth inhibition
- 参考文献：
1. Aronov, Alex M., et al. Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control. Journal of Medicinal Chemistry (2009), 52(20), 6362-6368. 2. Krepler C, et al. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.999 ml 9.993 ml 19.986 ml 5 mM 0.4 ml 1.999 ml 3.997 ml 10 mM 0.2 ml 0.999 ml 1.999 ml 50 mM 0.04 ml 0.2 ml 0.4 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
