S81227 |
MRT67307 |
源叶(MedMol) | 99% |
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- 产品描述: MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells
- 靶点: TBK1:19 nM (IC50, at 0.1 mM ATP);IKKε:160 nM (IC50, at 0.1 mM ATP);ULK2:38 nM (IC50);ULK1:45 nM (IC50);Autophagy;IκB/IKK; Autophagy
- 参考文献:
1. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. 2. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. 3. Zhu Z, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. 26.37Cancer Discov. 2014 Apr;4(4):452-65.
- 溶解性: DMSO : ≥ 100 mg/mL (215.24 mM)
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.152 ml 10.762 ml 21.524 ml 5 mM 0.43 ml 2.152 ml 4.305 ml 10 mM 0.215 ml 1.076 ml 2.152 ml 50 mM 0.043 ml 0.215 ml 0.43 ml
- 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)