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• 产品描述： AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.

• 靶点： Apoptosis;Autophagy;Pim;Apoptosis; Pim; Autophagy

• 体内研究：
  AZD1208在培养的MOLM-16细胞中引起细胞周期停滞和细胞凋亡。 这伴随着BAD,4EBP1和p70S6K磷酸化的剂量依赖性降低。 另外,AZD1208导致有效抑制来自骨髓抽吸物的原代AML细胞的集落生长并下调Pim靶标的磷酸化

• 细胞实验： AZD1208 is dissolved in DMSO. MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37?C and reading of fluorescence on a Tecan Infinite? 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment.

• 参考文献：
  1.Erika Keeton, et al. 53rd ASH Annual Meeting (2011) Abstract nr 1540

• 溶解性： DMSO:7.6  mg/mL  (20  mM)),with  gentle  warming

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.635 ml	13.176 ml	26.352 ml
  5 mM	0.527 ml	2.635 ml	5.27 ml
  10 mM	0.264 ml	1.318 ml	2.635 ml
  50 mM	0.053 ml	0.264 ml	0.527 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *