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• 产品描述： I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways

• 靶点： Epigenetic Reader Domain

• 体外研究：
  I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways. I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity. I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM. I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM. I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate. RT-PCR Cell Line: Kasumi-1 cells Concentration: 10 μM Incubation Time: 6 h Result: Showed 4 genes (CLEC1, 62 DUSP6, 63 FES64 and SAMSN165) that were strongly down-regulated and not by I-BET151.

• 参考文献：
  1. Natalie H Theodoulou, et al. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.01 ml	10.049 ml	20.098 ml
  5 mM	0.402 ml	2.01 ml	4.02 ml
  10 mM	0.201 ml	1.005 ml	2.01 ml
  50 mM	0.04 ml	0.201 ml	0.402 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *