货号	规格	价格	上海	北京	珠海	南京	武汉
S81431-5mg	≥99%	￥279.00 S81431-5mg ￥279.00 现货	10 10	-	-	-	-
S81431-10mg	≥99%	￥479.00 S81431-10mg ￥479.00 现货	10 0 10	-	-	-	-
S81431-25mg	≥99%	￥1050.00 S81431-25mg ￥1050.00 现货	7 7	-	-	-	-
S81431-50mg	≥99%	￥1980.00 S81431-50mg ￥1980.00 现货	7 7	-	-	-	-
S81431-100mg	≥99%	￥2880.00 S81431-100mg ￥2880.00 现货	5 5	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM)

靶点：

5-HT6 Receptor:8.92-9.02 (pKi);5-HT1D Receptor:6.55 (pKi);5-HT1A Receptor:6.35 (pKi);5-HT1B Receptor;6.05 (pKi);5-HT1F Receptor:5.95 (pKi);5-HT2A Receptor:5.62 (pKi);5-HT2B Receptor:5.41 (pKi);5-HT7 Receptor:5.39 (pKi);5-HT4 Receptor:5.27 (pKi);5-HT1E Receptor:<4.99 (pKi);Human 5-HT2C Receptor:5.73 (pKi);5-HTReceptor

体外研究：

SB 271046 Hydrochloride (SB 271046A) shows pKi values of 6.55, 6.35, 6.27, 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT1D, 5-HT1A, D3, 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively. SB-271046 Hydrochloride competitively antagonizes 5-HT-induced stimulation of adenylyl cyclase activity with a pA2 of 8.71

体内研究：

SB 271046 Hydrochloride (10 mg/kg; p.o.) produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ⩽0.1 mg/kg p.o. and maximum effect at 4 h post-dose Animal Model: Male Sprague Dawley rats Dosage: 10 mg/kg Administration: P.o. Result: Produced an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ⩽0.1 mg kg−1 p.o. and maximum effect at 4 h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB-271046 (EC50 of 0.16 μM) and brain concentrations of 0.01-0.04 μM at Cmax.

参考文献：

1. Routledge C, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol. 2000;130(7):1606-1612.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃;干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.047 ml	10.236 ml	20.473 ml
5 mM	0.409 ml	2.047 ml	4.095 ml
10 mM	0.205 ml	1.024 ml	2.047 ml
50 mM	0.041 ml	0.205 ml	0.409 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

SB 271046盐酸盐

SB 271046 (Hydrochloride)

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)