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- 产品描述: Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
- 靶点: HDAC;Virus Protease;VirusProtease; HDAC
- 体内研究:
In chick embryos, inhibition of HDAC6 activity by Tubacin reduces the formation of new blood vessels in matrigel/nylon mesh. In angioreactors implanted in mice, Tubacin also impairs the formation of new blood vessels.
- 细胞实验: Cell lines: Drug-sensitive (MM.1S,U266,INA-6,and RPMI8226) and drug-resistant (RPMI-LR5 and RPMI-Dox40) MM cell lines. Concentrations: ~20 μM. Incubation Time: 72 hours. Method:The inhibitory effect of bortezomib and/or tubacin on MM cell growth is assessed by measuring 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) dye absorbance.All experiments are performed in quadruplicate.
- 动物实验: Animal Models: Athymic nude mice implanted with angioreactorsFormulation: DMSODosages: --Administration: Tubacin is filled in semiclosed angioreactors, and then implanted into the mice.
- 参考文献:
1. Li D, et al. Protein Cell. 2011, 2(2), 150-160. 2. Butler KV, et al. J Am Chem Soc. 2010, 132(31), 10842-0846. 3. Hideshima T, et al. Proc Natl Acad Sci U S A. 2005, 102(24), 8567-8572. 4. Marcus AI, et al. Cancer Res. 2005, 65(9), 3883-3893. 5. Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18(5). 6. Haggarty SJ, et al. Proc Natl Acad Sci U S A. 2003, 100(8), 4389-4394.
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 1.385 ml 6.927 ml 13.853 ml 5 mM 0.277 ml 1.385 ml 2.771 ml 10 mM 0.139 ml 0.693 ml 1.385 ml 50 mM 0.028 ml 0.139 ml 0.277 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)