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• 产品描述： Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity

• 靶点： Human Endogenous Metabolite;Others; Antifolate

• 体内研究：
  Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)

• 参考文献：
  1. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. 2. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.

• 溶解性： H2O  :  10  mg/mL  (16.62  mM;  Need  ultrasonic)    DMSO  :  1  mg/mL  (1.66  mM;  ultrasonic  and  warming  and  heat  to  80°C)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.955 ml	9.775 ml	19.55 ml
  5 mM	0.391 ml	1.955 ml	3.91 ml
  10 mM	0.196 ml	0.978 ml	1.955 ml
  50 mM	0.039 ml	0.196 ml	0.391 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *