• 提示：详情请下载说明书。

• 产品描述： Importazole is an inhibitor of the nuclear transport receptor importin-β.

• 靶点： Apoptosis;Apoptosis; Others

• 细胞实验： For all import and export experiments, HEK 293 cells stably expressing NFAT-GFP are grown on glass coverslips to approximately 50% confluency prior to drug treatment. In all cases, importazole is used at 40 μM and leptomycin B is used at 10 ng/ml. For controls, DMSO is used at a concentration of 0.4%. Ionomycin is added at 1.25 μM. Importazole and leptomycin B treatments are all for 1 hour. In all experiments cells are fixed with 4% formaldehyde prior to fluorescence microscopy. DNA is visualized with 1 μg/ml Hoechst dye. For quantification, 100 cells from each condition are analyzed and the percentage that shows nuclear accumulation of NFAT-GFP calculated.(Only for Reference)

• 参考文献：
  1.Soderholm JF, et al. ACS Chem Biol. 2011, 6(7):700-8. 2.Yan WQ, et al. Zhonghua Xue Ye Xue Za Zhi. 2013, 34(4):323-6.

• 溶解性： DMSO:33  mg/mL    Ethanol:28  mg/mL(87.9  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.141 ml	15.703 ml	31.406 ml
  5 mM	0.628 ml	3.141 ml	6.281 ml
  10 mM	0.314 ml	1.57 ml	3.141 ml
  50 mM	0.063 ml	0.314 ml	0.628 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *