FR 180204

    
99%

FR 180204

源叶(MedMol)
S81545 一键复制产品信息
865362-74-9
C18H13N7
327.34
货号 规格 价格 上海 北京 武汉 南京 购买数量
S81545-5mg 99% ¥430.00 3 - - -
S81545-10mg 99% ¥670.00 6 - - -
S81545-25mg 99% ¥1290.00 3 - - -
产品介绍 参考文献(1篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively

产品描述: FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively
靶点: ERK1:0.31 μM (Ki);ERK2:0.14 μM (Ki);ERK2:0.33 μM (IC50);ERK1:0.51 μM (IC50);Apoptosis; ERK
体内研究: FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice. In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters
参考文献: 1. Ohori M, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63. 2. Ohori M, et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374(4):311-6. 3. Honda M, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29(5-6):667-74 4. Sreekanth GP, et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26
溶解性: DMSO  :  ≥  50  mg/mL  (152.75  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.055 ml 15.275 ml 30.549 ml
5 mM 0.611 ml 3.055 ml 6.11 ml
10 mM 0.305 ml 1.527 ml 3.055 ml
50 mM 0.061 ml 0.305 ml 0.611 ml
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