| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81575-5mg买3赠1 |
99.40% | ￥196.00 |
5 | - | - | - | - |
|
S81575-10mg买3赠1 |
99.40% | ￥290.00 |
4 | - | - | - | - |
|
S81575-25mg买3赠1 |
99.40% | ￥580.00 |
7 | - | - | - | - |
|
S81575-50mg买3赠1 |
99.40% | ￥930.00 |
2 | - | - | - | - |
|
S81575-100mg买3赠1 |
99.40% | ￥1660.00 |
4 | - | - | - | - |
|
S81575-200mg买3赠1 |
≥99% | ￥3060.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | FPS-ZM1 is a high-affinity RAGE inhibitor with a Ki of 25 nM. | ||||||||||||||||||||
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| 靶点： | Ki: 25 nM (RAGE) | ||||||||||||||||||||
| 体内研究： | FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier. In aged APPsw/0 mice overexpressing human Aβ-precursor protein, a transgenic mouse model of AD with established Aβ pathology, FPS-ZM1 inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. In brain, FPS-ZM1 binds exclusively to RAGE, which inhibits β-secretase activity and Aβ production and suppresses microglia activation and the neuro-inflammatory response. FPS-ZM1 treatment reduces the level of Aβ1-40 and Aβ1-42 in AGEs Rats. It Inhibits AGEs-mediated increase of Aβ-metabolism-related proteins and downregulates AGEs-mediated increase of pro-inflammatory cytokines in the hippocampus. FPS-ZM1 up-Regulates anti-oxidant defense system and attenuated AGEs induced memory impairment in AGEs rats | ||||||||||||||||||||
| 参考文献： | 1. Deane R, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr;122(4):1377-92. 2. Hong Y, et al. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res. 2016 May;41(5):1192-9. 3. Lian YJ, et al. Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. Brain Behav Immun. 2017 Jan;59:322-332. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (305.02 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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