货号	规格	价格	上海	北京	珠海	南京	武汉
S81580-1mg	99.90%	￥60.00 S81580-1mg ￥60.00 现货	1789 >10	-	-	-	-
S81580-5mg	99.90%	￥140.00 S81580-5mg ￥140.00 现货	361 >10	-	-	-	-
S81580-10mg	99.90%	￥200.00 S81580-10mg ￥200.00 现货	182 >10	-	-	-	-
S81580-25mg	99.90%	￥290.00 S81580-25mg ￥290.00 现货	77 >10	-	-	-	-
S81580-50mg	≥99%	￥520.00 S81580-50mg ￥520.00 现货	35 >10	-	-	-	-
S81580-100mg	≥99%	￥1000.00 S81580-100mg ￥1000.00 现货	17 >10	-	-	-	-

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产品描述：

IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM

靶点：

IKKβ;NF-Κb:1.2 μM (IC50);IκB/IKK

体内研究：

Daily administration with 5 mg/kg IMD-0354 significantly suppresses tumor expansion in nude mice implanted with established MDA-MB-231 tumors. In mice treated with IMD-0354, tumor progression is restrained. The number of infiltrating cells in aqueous humor is 53.6±9.8×105, 72.5±17.0×105, 127.25±32.0×105, and 132.0±25.0×105 cells/mL in rats treated with 30, 10, 3, or 0 mg/kg of IMD-0354, respectively. The total protein concentrations of aqueous humor are 92.6±3.1 mg/mL, 101.5±6.8 mg/mL, 112.6±1.9 mg/mL, and 117.33±1.8 mg/mL in rats treated with 30, 10, 3, and 0 mg/kg of IMD-0354, respectively.

参考文献：

1. Tanaka A, et al. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood. 2005 Mar 15;105(6):2324-31. 2. Li YR, et al. Study of the inhibitory effects on TNF-α-induced NF-κB activation of IMD0354 analogs. Chem Biol Drug Des. 2017 Dec;90(6):1307-1311. 3. Tanaka A, et al. A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 2006 Jan 1;66(1):419-26. 4. Lennikov A, et al. Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats. Mol Vis. 2012;18:2586-97.

溶解性：

DMSO : ≥ 100 mg/mL (260.64 mM) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.606 ml	13.032 ml	26.064 ml
5 mM	0.521 ml	2.606 ml	5.213 ml
10 mM	0.261 ml	1.303 ml	2.606 ml
50 mM	0.052 ml	0.261 ml	0.521 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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IMD 0354