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• 产品描述： Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM

• 靶点： Ki: 8 nM (NA reuptake);AdrenergicReceptor; Norepinephrine

• 体内研究：
  Reboxetine mesylate (30 mg/kg; i.p.) significantly decreases the immobility time in the mice depression models

• 参考文献：
  1. Wong, E.H., et al., Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol Psychiatry, 2000. 47(9): p. 818-29. 2. Versiani, M., et al., Reboxetine, a unique selective NRI, prevents relapse and recurrence in long-term treatment of major depressive disorder. J Clin Psychiatry, 1999. 60(6): p. 400-6. 3. M Leskiewicz, et al. Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: a involvement of extracellular regulated kinase (ERK1/2). Neurochem Int. 2013 Nov;63(5):354-62.

• 溶解性： DMSO  :  125  mg/mL  (305.25  mM;  Need  ultrasonic)    H2O  :  50  mg/mL  (122.10  mM;  Need  ultrasonic)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.442 ml	12.21 ml	24.42 ml
  5 mM	0.488 ml	2.442 ml	4.884 ml
  10 mM	0.244 ml	1.221 ml	2.442 ml
  50 mM	0.049 ml	0.244 ml	0.488 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *