| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 南京 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81688-1mg |
98.10% | ￥112.00 |
9 | - | - | - | - |
|
S81688-5mg |
98.10% | ￥210.00 |
9 | - | - | - | - |
|
S81688-10mg |
98.10% | ￥330.00 |
8 | - | - | - | - |
|
S81688-50mg |
98.10% | ￥990.00 |
7 | - | - | - | - |
|
S81688-100mg |
≥98% | ￥1500.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Esonarimod is an antirheumatic drug. | ||||||||||||||||||||
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| 靶点： | IL Receptor;ILReceptor | ||||||||||||||||||||
| 体内研究： | After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found | ||||||||||||||||||||
| 细胞实验： | For in vitro experiment, Esonarimod (KE-298) is dissolved in ethanol and diluted with culture medium or distilled water.RAW264.7 cells are used in this study. For NO production, RAW264.7 cells [2×105/0.2 mL of RPMI-1640 supplemented by 10% heat inactivated fetal bovine serum (FBS), penicillin G (100 U/mL), and streptomycin (100 μg/mL)] are stimulated with 100 ng/mL of Escherichia coli 026:B6 lipopolysaccharide in the presence of Esonarimod (KE-298) (0, 10, 30, 100, 200, 300 μg/mL) in 96 well plates and incubated 24 h at 37°C in an atmosphere of 5% CO2 in air. After incubation, the supernatants are collected and assayed for nitrite (NO2-) instead of NO | ||||||||||||||||||||
| 动物实验： | Seven-week-old male Wistar rats is administered Esonarimod (5 mg/kg once daily) orally by gastric intubation | ||||||||||||||||||||
| 参考文献： | 1.Inoue T, et al. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. J Rheumatol. 2001 Jun;28(6):1229-37. 2.Hasegawa M, et al. Formation of a disulfide protein conjugate of the SH-group-containing metabolite (M-I) ofesonarimod (KE-298) and its elimination in rats. J Pharm Pharmacol. 2002 Apr;54(4):493-8. | ||||||||||||||||||||
| 溶解性： | DMSO:10 mM | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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