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• 产品描述： AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )

• 靶点： Autophagy;Retinoid Receptor;RetinoidReceptor; Autophagy

• 体内研究：
  Modulation of the RARα/β to RARγ expression in mammary glands of normal mice, oncomice, and human mammary cell lines through the alteration of RAR-target gene expression affected cell proliferation, survival and tumor growth.?Treatment of MMTV-Myc mice with the RARα-selective agonist Am580 led to significant inhibition of mammary tumor growth (~90%, P<0.001), lung metastasis (P<0.01) and extended tumor latency in 63% of mice.?In these mice, RARα responsive genes such as Cyp26A1, E-cadherin, cellular retinol-binding protein 1 (CRBP1) and p27, were up-regulated

• 细胞实验： Ishikawa cells were transfected with control siRNA or siRNA specific against the RARα gene.Cells were treated with vehicle control or AM580 for 18 h.Cells were stained with trypan blue and counted

• 动物实验： The effects of c-Myc on RAR isotype expression were evaluated in normal mouse mammary epithelium, mammary tumor cells obtained from the MMTV-Myc transgenic mouse model as well as human normal immortalized breast epithelial and breast cancer cell lines.?The in vivo effect of the RARα-selective agonist 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carboxamido]benzoic acid (Am580) was examined in the MMTV-Myc mouse model of mammary tumorigenesis

• 参考文献：
  1.Bosch A , Bertran S P , Lu Y , et al. Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis[J]. Breast Cancer Research,14,4(2012-08-24), 2012, 14(4). 2.Cheng Y H , Utsunomiya H , Pavone M E , et al. Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms[J]. Journal of Molecular Endocrinology, 2011, 46(2):139-153.

• 溶解性： DMSO:45  mg/mL  (128.04  mM)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.845 ml	14.227 ml	28.454 ml
  5 mM	0.569 ml	2.845 ml	5.691 ml
  10 mM	0.285 ml	1.423 ml	2.845 ml
  50 mM	0.057 ml	0.285 ml	0.569 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *