货号	规格	价格	上海	北京	珠海	重庆	武汉
S82153-1mg促销	99.32%	￥380.00 ￥342.00 S82153-1mg ￥342.00 现货	4 4	-	-	-	-
S82153-5mg促销	99.32%	￥780.00 ￥702.00 S82153-5mg ￥702.00 现货	4 4	-	-	-	-
S82153-25mg促销	99.32%	￥2500.00 ￥2250.00 S82153-25mg ￥2250.00 现货	3 3	-	-	-	-
S82153-100mg促销	99.32%	￥6000.00 ￥5400.00 S82153-100mg ￥5400.00 现货	1 1	-	-	-	-

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产品描述：

IDE1 is an inducer of definitive endoderm 1.

靶点：

Others

体外研究：

IDE1 enhances the definitive endoderm (DE) differentiation of human-induced pluripotent stem cells (hiPSCs) with Activin A/Wnt3a being significantly more potent in both 2D and 3D cultures compared to IDE1. IDE1 could efficiently induces DE differentiation through various protocols in vitro. Treatment of the hiPSCs-derived EBs with IDE-1 shows minor increase (p<0.01) of DE-markers cells compared to Activin A/Wnt3a treatment. IDE1 possess several advantages over other inducing factors including high permeability, influence, diversity, low cost, and easy to use and for the first time, Melton’s team showed that Activin A can be substituted by two cell-permeable small molecules, IDE1 and IDE2. IDE1 could induce phosphorylation of Smad2 after incubation for 24 h or more at levels comparable to those induced by Activin A treatment. Treatment of hiPSCs with IDE1 (2 mM) also leads to endodermal differentiation but with a significantly lower efficiency than Activin A/Wnt3a

参考文献：

1. Hoveizi E, et al. Definitive endoderm differentiation of human-induced pluripotent stem cells using signaling molecules and IDE1 in three-dimensional polymer scaffold. J Biomed Mater Res A. 2014 Nov;102(11):4027-36.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.265 ml	16.323 ml	32.646 ml
5 mM	0.653 ml	3.265 ml	6.529 ml
10 mM	0.326 ml	1.632 ml	3.265 ml
50 mM	0.065 ml	0.326 ml	0.653 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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