货号	规格	价格	上海	北京	珠海	武汉
S82498-1mg	99.40%	￥130.00 S82498-1mg ￥130.00 现货	9 9	-	-	-
S82498-5mg	99.40%	￥290.00 S82498-5mg ￥290.00 现货	6 6	-	-	-
S82498-10mg	99.40%	￥500.00 S82498-10mg ￥500.00 现货	6 6	-	-	-
S82498-25mg	99.40%	￥900.00 S82498-25mg ￥900.00 现货	5 5	-	-	-
S82498-50mg促销	99.40%	￥1500.00 ￥1200.00 S82498-50mg ￥1200.00 现货	4 4	-	-	-
S82498-100mg促销	≥98%	￥2400.00 ￥1920.00 S82498-100mg ￥1920.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions.

靶点：

IC50: 50-70mg/kg (FAAH, rat brain regions);FAAH; Autophagy

体外研究：

ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC50s of 50-70mg/kg (i.p.) in various brain regions. IC50 values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)

体内研究：

In January 2016, severe adverse events (SAE) occurs in the Phase I clinical trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought

参考文献：

1. Tong J, et al. Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain. J Cereb Blood Flow Metab. 2016 Sep 20. 2. Kaur R, et al. What failed BIA 10-2474 Phase I clinical trial? Global speculations and recommendations for future Phase I trials. J Pharmacol Pharmacother. 2016 Jul-Sep;7(3):120-6

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.329 ml	16.647 ml	33.294 ml
5 mM	0.666 ml	3.329 ml	6.659 ml
10 mM	0.333 ml	1.665 ml	3.329 ml
50 mM	0.067 ml	0.333 ml	0.666 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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