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• 产品描述： Telacebec (Q203, IAP6) 是一种新型抗结核药物，通过抑制分枝杆菌细胞色素 bc1 复合物来靶向结核分枝杆菌（Mycobacterium tuberculosis） 细胞能量的产生。Telacebec 对结核分枝杆菌 H37Rv 具有活性，在培养基中的 MIC50 为 2.7 nM

• 靶点： Mycobacterium tuberculosis H37Rv:2.7 nM(MIC50);Antibacterial; Antibiotic

• 体外研究：
  Telacebec (Q203) inhibits the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range.

• 体内研究：
  Telacebec (Q203) is efficacious in a mouse model of tuberculosis at a dose less than 1 mg/kg body weight and displays pharmacokinetic and safety profiles compatible with once-daily dosing.

• 细胞实验： Cell lines: Raw 264.7 cells Concentrations: 0.1 nM-100 µM Incubation Time: -- Method: Telacebec (Q203) are incubated with macrophages previously. Raw 264.7 cells (American Type Culture Collection TIB-71) were infected with M. tuberculosis H37Rv-GFP at a multiplicity of infection of 2:1 and dispensed into plates. After 5 d of infection, macrophages were stained with Syto 60 for Image acquisition.

• 动物实验： Animal Models: A high dose of M. tuberculosis H37Rv infected-acute tuberculosis BALB/c mouse model Dosages: 0.4, 2, 10 mg/kg Administration: Oral gavage

• 参考文献：
  1. Veronique R de Jager, et al. Telacebec (Q203), a New Antituberculosis Agent. N Engl J Med. 2020 Mar 26;382(13):1280-1281. 2. Kevin Pethe, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.795 ml	8.977 ml	17.953 ml
  5 mM	0.359 ml	1.795 ml	3.591 ml
  10 mM	0.18 ml	0.898 ml	1.795 ml
  50 mM	0.036 ml	0.18 ml	0.359 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *