S82895 |
PAGOCLONE |
源叶(MedMol) | 98% |
- 产品描述: Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders.
- 靶点: GABA Receptor
- 体内研究:
Pagoclone (3 mg/kg, p.o.) has significant anxiolytic-like activity, but at all three doses tested (0.3, 1 and 3 mg/kg p.o.) it produces a significant reduction in the total distance travelled. Pagoclone (3 mg/kg, p.o.) produces a dose-dependent increase in time spent on the open arms compared to control. Pagoclone (1, 3 or 10 mg/kg) lowers the cumulative chain-pulling response in the response sensitivity test. Plasma pagoclone concentrations are dose-dependent but not linear, with plasma concentrations of pagoclone being 0.4±0.1, 1.1±0.2 and 2.2±0.2 ng/mL, respectively. Pagoclone (0.3, 1 or 3 mg/kg) reduces locomotor activity in rats in a dose dependent manner
- 参考文献:
1. Atack JR, et al. The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology. 2006 May;50(6):677-89.
- 溶解性: Soluble in DMSO
- 保存条件: 2-8℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.452 ml 12.258 ml 24.516 ml 5 mM 0.49 ml 2.452 ml 4.903 ml 10 mM 0.245 ml 1.226 ml 2.452 ml 50 mM 0.049 ml 0.245 ml 0.49 ml
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输入产品批号:
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)