• 提示：详情请下载说明书。

• 产品描述： KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM)

• 靶点： CLK1:19.7 nM (IC50);CLK3:530 nM (IC50);DYRK1A:55.2 nM (IC50);Others

• 体外研究：
  KH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells. KH-CB19 (50 μM; 6 h) inhibits the disruption by CLK4 in A549 cells. Western Blot Analysis Cell Line: Human microvascular endothelial cells (HMEC-1) Concentration: 10 μM Incubation Time: 1 hour Result: Led to a reduced phosphorylation of SRp75, SRp55, and SRp20 compared with non TNF-α-stimulated controls.Led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.

• 参考文献：
  1. Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. 2. Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.957 ml	14.785 ml	29.569 ml
  5 mM	0.591 ml	2.957 ml	5.914 ml
  10 mM	0.296 ml	1.478 ml	2.957 ml
  50 mM	0.059 ml	0.296 ml	0.591 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *