| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 南京 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83116-1mg一口价 |
≥98% | ￥180.00 ￥144.00 |
>10 | - | - | - | - |
|
S83116-2mg一口价 |
≥98% | ￥250.00 ￥200.00 |
>10 | - | - | - | - |
|
S83116-5mg一口价 |
≥98% | ￥510.00 ￥408.00 |
>10 | - | - | - | - |
|
S83116-10mg一口价 |
≥98% | ￥870.00 ￥696.00 |
>10 | - | - | - | - |
|
S83116-25mg |
≥98% | ￥1740.00 |
>10 | - | - | - | - |
|
S83116-50mg |
≥98% | ￥2180.00 |
10 | - | - | - | - |
|
S83116-100mg |
≥98% | ￥3280.00 |
5 | - | - | - | - |
|
| 产品描述： | Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease | ||||||||||||||||||||
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| 靶点： | Glucosylceramide synthase;Transferase | ||||||||||||||||||||
| 体外研究： | Ibiglustat (SAR402671) (1 μM, 15 days; Fabry disease (FD) cells) is close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes | ||||||||||||||||||||
| 参考文献： | 1. Viel C, et al. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Sci Rep. 2021;11(1):20945. Published 2021 Oct 22. 2. Peterschmitt MJ, et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021;10(1):86-98. 3. Stojkovska I, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2018;373(1):51-60. 4. Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京