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• 产品描述： GV-58 is a novel N- and P/Q-type calcium (Ca2+) channel agonist with EC50s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca2+ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research

• 靶点： N-type calcium channel:7.21 μM (EC50);P/Q-type calcium channel:8.81 μM (EC50);CalciumChannel

• 体外研究：
  GV-58 (50 μM; 30 min) restores function in LEMS passive transfer neuromuscular junction. Cell Viability Assay Cell Line: Upper arm muscle isolated from LEMS mice Concentration: 50 μM Incubation Time: 30 min Result: Increased the mEPP frequency from 3.27 s−1 in vehicle controls to 10.45 s−1.Showed a slight facilitation followed by depression to ∼94% at the final EPP in the train.

• 参考文献：
  1. Tarr TB, et al. Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. J Neurosci. 2013 Jun 19;33(25):10559-67. 2. Tarr TB, et al. Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist. J Physiol. 2014 Aug 15;592(16):3687-96. 3. Meriney SD, et al. Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads. Ann N Y Acad Sci. 2018 Jan;1412(1):73-81.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.67 ml	13.351 ml	26.702 ml
  5 mM	0.534 ml	2.67 ml	5.34 ml
  10 mM	0.267 ml	1.335 ml	2.67 ml
  50 mM	0.053 ml	0.267 ml	0.534 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *