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• 产品描述： Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM

• 靶点： hACC1(Cell-free assay):2.1 nM; hACC2(Cell-free assay):6.1 nM;Acetyl-CoACarboxylase

• 体外研究：
  When ND-630 and [14C]acetate were administered to Hep-G2 cells for 4 h, ND-630 inhibited FASyn with EC50 values of 66 nM in cells cultured in medium containing. When ND-630 and[14C]palmitate were administered to C2C12 cells for 6 h, ND-630 increased both the release of [14C]O2 and the production of[14C]acid-soluble material

• 体内研究：
  When administered chronically to rats with diet-induced obesity, ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia

• 细胞实验： Cell lines: HepG2 cells Concentrations: 2.1 nM (ACC1); 6.1 nM (ACC2) Incubation Time: 1 h Method: Cells were treated with varying concentrations of ND-630.

• 动物实验： Animal Models: Male Sprague–Dawley rats Dosages: 10 mg/kg Administration: o.g.

• 参考文献：
  1. Harriman G,et al. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A.2016 29;113(13):E1796-805.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.756 ml	8.778 ml	17.555 ml
  5 mM	0.351 ml	1.756 ml	3.511 ml
  10 mM	0.176 ml	0.878 ml	1.756 ml
  50 mM	0.035 ml	0.176 ml	0.351 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *