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• 产品描述： HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1

• 靶点： IC50: 0.67 μM (PCA-1);Others

• 体外研究：
  HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells

• 体内研究：
  HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model. HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration. Animal Model: Nude mice Dosage: 32 mg/kg Administration: Subcutaneous injection; daily; 6 days Result: Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration.

• 参考文献：
  1. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.141 ml	15.705 ml	31.41 ml
  5 mM	0.628 ml	3.141 ml	6.282 ml
  10 mM	0.314 ml	1.57 ml	3.141 ml
  50 mM	0.063 ml	0.314 ml	0.628 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *