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• 产品描述： C75 trans (trans-C75, (±)-C75) 是一种 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制剂，在成株试验和球体生长测定中的IC50值分别为35 μM和50 μM。C75 可用作研究代谢紊乱和癌症中脂肪酸合成的工具

• 靶点： FASN(clonogenic assay):35 μM;FASN(spheroid growth assay):50 μM;FattyAcidSynthase

• 体内研究：
  C75 inhibits fatty acid synthesis and in vivo mammary cancer development. C75 treatment prevents mammary cancer development and retards mammary development in neu-N transgenic mice.

• 细胞实验： Cell lines: PC3 cells, LNCaP cells Concentrations: 5 μM, 25 μM, 35 μM, 50 μM Incubation Time: 3 h, 6 h, 24 h Method: PC3 cells are seeded in 25 cm2 flasks at 105 cells/flask. When cultures are in exponential growth phase, media is removed and replaced with fresh drug-containing media. Cells are then incubated for 24 h at 37℃ in 5% CO2. To determine optimal sequencing of therapeutic agents, three different combination treatment schedules are assessed: 1. radiation and C75 administered simultaneously; 2. radiation administered 24 h before C75; and 3. radiation administered 24 h after C75. After treatment, cells are seeded for clonogenic survival assay.

• 动物实验： Animal Models: neu-N transgenic mice, FVB/N mice Dosages: 30mg/kg Administration: IP

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃;干燥

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.932 ml	19.66 ml	39.321 ml
  5 mM	0.786 ml	3.932 ml	7.864 ml
  10 mM	0.393 ml	1.966 ml	3.932 ml
  50 mM	0.079 ml	0.393 ml	0.786 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *