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• 产品描述： BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).

• 靶点： Sigma receptor;Sigmareceptor

• 体内研究：
  BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls

• 动物实验： Rats (controls, N=11;?dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design.?sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design

• 参考文献：
  1.Nieto F R , Cruz Miguel Cendán, Cristina Sánchez-Fernández, et al. Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice[J]. The journal of pain: official journal of the American Pain Society, 2012, 13(11):1107-1121. 2.Sabino V , Cottone P , Zhao Y , et al. The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking[J]. Neuropsychopharmacology, 2009, 34(6):1482-1493.

• 溶解性： H2O:50  mg/mL  (144.46  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.889 ml	14.446 ml	28.892 ml
  5 mM	0.578 ml	2.889 ml	5.778 ml
  10 mM	0.289 ml	1.445 ml	2.889 ml
  50 mM	0.058 ml	0.289 ml	0.578 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *