WHI-P97

    
99%

WHI-P97

源叶(MedMol)
S84395 一键复制产品信息
211555-05-4
C16H13Br2N3O3
455.11
WHI-P97; HMS3265E23;
货号 规格 价格 上海 北京 武汉 南京 购买数量
S84395-1mg 99% ¥180.00 10 - - -
S84395-2mg 99% ¥300.00 10 - - -
S84395-5mg 99% ¥440.00 7 - - -
S84395-10mg 99% ¥700.00 6 - - -
S84395-25mg 99% ¥1330.00 5 - - -
S84395-50mg 99% ¥2010.00 货期:2-3天 - - -
S84395-100mg 99% ¥2980.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo

产品描述: WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo
靶点: JAK3:11 μM (IC50);JAK
体内研究: WHI-P97 is very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 μg/kg to 50 mg/kg, and LD10 is not reached at a 50 mg/kg dose level when administered as a single i.p. or i.v. bolus dose. WHI-P97 (i.v. injection; 40 mg/kg; single dose) has an elimination half-life (t1/2) of 58.9 min and systemic clearance (CL) of 891 ml/h/kg in CD-1 mice and a t1/2 of 84.2 min and CL of 1513 ml/h/kg in BALB/c mice. The values for AUC and Cmax are 107.3 μM and 296.7 μM, respectively, in CD-1 mice. And the IC50 values are 58.4 μM and 212.7 μM, respectively, in BALB/c mice. The large volume of distribution are 322 ml/kg in CD-1 mice and 415 ml/kg in BALB/c mice. WHI-P97 (intraperitoneal injection; 40 mg/kg; 24 days) prevents ovalbumin-sensitized mice the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion in mice. WHI-P97 inhibits the eosinophil recruitment to the airway lumen after the ovalbumin challenge in a dose-dependent fashion
参考文献: 1. R Malaviya, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther. 2000 Dec;295(3):912-26.
溶解性: DMSO  :  3.33  mg/mL  (7.32  mM;  ultrasonic  and  warming  and  heat  to  80°C)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.197 ml 10.986 ml 21.973 ml
5 mM 0.439 ml 2.197 ml 4.395 ml
10 mM 0.22 ml 1.099 ml 2.197 ml
50 mM 0.044 ml 0.22 ml 0.439 ml
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参考文献

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