| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S84395-1mg |
99.5% | ￥180.00 | 10 | - | - | - |
|
S84395-2mg |
99.5% | ￥300.00 | 10 | - | - | - |
|
S84395-5mg |
99.5% | ￥440.00 | 7 | - | - | - |
|
S84395-10mg |
99.5% | ￥700.00 | 6 | - | - | - |
|
S84395-25mg |
99.5% | ￥1330.00 | 5 | - | - | - |
|
S84395-50mg |
≥99% | ￥2010.00 | 货期：2-3天 | - | - | - |
|
S84395-100mg |
≥99% | ￥2980.00 | 货期：2-3天 | - | - | - |
|
WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo
| 产品描述： | WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo | ||||||||||||||||||||
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| 靶点： | JAK3:11 μM (IC50);JAK | ||||||||||||||||||||
| 体内研究： | WHI-P97 is very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 μg/kg to 50 mg/kg, and LD10 is not reached at a 50 mg/kg dose level when administered as a single i.p. or i.v. bolus dose. WHI-P97 (i.v. injection; 40 mg/kg; single dose) has an elimination half-life (t1/2) of 58.9 min and systemic clearance (CL) of 891 ml/h/kg in CD-1 mice and a t1/2 of 84.2 min and CL of 1513 ml/h/kg in BALB/c mice. The values for AUC and Cmax are 107.3 μM and 296.7 μM, respectively, in CD-1 mice. And the IC50 values are 58.4 μM and 212.7 μM, respectively, in BALB/c mice. The large volume of distribution are 322 ml/kg in CD-1 mice and 415 ml/kg in BALB/c mice. WHI-P97 (intraperitoneal injection; 40 mg/kg; 24 days) prevents ovalbumin-sensitized mice the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion in mice. WHI-P97 inhibits the eosinophil recruitment to the airway lumen after the ovalbumin challenge in a dose-dependent fashion | ||||||||||||||||||||
| 参考文献： | 1. R Malaviya, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther. 2000 Dec;295(3):912-26. | ||||||||||||||||||||
| 溶解性： | DMSO : 3.33 mg/mL (7.32 mM; ultrasonic and warming and heat to 80°C) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京