货号	规格	价格	上海	北京	珠海	南京	武汉
S84395-1mg一口价	99.50%	￥144.00 S84395-1mg ￥144.00 现货	9 9	-	-	-	-
S84395-2mg一口价	99.50%	￥240.00 S84395-2mg ￥240.00 现货	9 9	-	-	-	-
S84395-5mg一口价	99.50%	￥352.00 S84395-5mg ￥352.00 现货	7 7	-	-	-	-
S84395-10mg一口价	99.50%	￥560.00 S84395-10mg ￥560.00 现货	6 6	-	-	-	-
S84395-25mg	99.50%	￥1330.00 S84395-25mg ￥1330.00 现货	5 5	-	-	-	-
S84395-50mg	≥99%	￥2010.00 S84395-50mg ￥2010.00 2-3天	0 货期：2-3天	-	-	-	-
S84395-100mg	≥99%	￥2980.00 S84395-100mg ￥2980.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo

靶点：

JAK3:11 μM (IC50);JAK

体内研究：

WHI-P97 is very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 μg/kg to 50 mg/kg, and LD10 is not reached at a 50 mg/kg dose level when administered as a single i.p. or i.v. bolus dose. WHI-P97 (i.v. injection; 40 mg/kg; single dose) has an elimination half-life (t1/2) of 58.9 min and systemic clearance (CL) of 891 ml/h/kg in CD-1 mice and a t1/2 of 84.2 min and CL of 1513 ml/h/kg in BALB/c mice. The values for AUC and Cmax are 107.3 μM and 296.7 μM, respectively, in CD-1 mice. And the IC50 values are 58.4 μM and 212.7 μM, respectively, in BALB/c mice. The large volume of distribution are 322 ml/kg in CD-1 mice and 415 ml/kg in BALB/c mice. WHI-P97 (intraperitoneal injection; 40 mg/kg; 24 days) prevents ovalbumin-sensitized mice the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion in mice. WHI-P97 inhibits the eosinophil recruitment to the airway lumen after the ovalbumin challenge in a dose-dependent fashion

参考文献：

1. R Malaviya, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther. 2000 Dec;295(3):912-26.

溶解性：

DMSO : 3.33 mg/mL (7.32 mM; ultrasonic and warming and heat to 80°C)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.197 ml	10.986 ml	21.973 ml
5 mM	0.439 ml	2.197 ml	4.395 ml
10 mM	0.22 ml	1.099 ml	2.197 ml
50 mM	0.044 ml	0.22 ml	0.439 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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