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• 产品描述：

  C75 (4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylicacid)是一种更稳定的浅蓝菌素合成模拟物，抑制脂肪酸合酶(fatty-acid synthase, FAS/FASN)，IC50为15.53 μM，在多种癌症模型中具有潜在的治疗作用。C75也是一种有效的CPT1A激活剂。

• 靶点： FAS/FASN:15.53 μM;FattyAcidSynthase

• 体内研究：
  C75, an alpha-methylene-gamma-butyrolactone, reduces adipose tissue and fatty liver in treated DIO mice, despite high levels of malonyl-CoA

• 细胞实验： Cell lines: PC3, UVW and LNCaP cell lines, SK-N-BE(2c) and MCF7 cells Concentrations: 35 µM Incubation Time: 24 h Method: Cells are seeded in 25 cm2 flasks at 105 cells/flask. When cultures are in exponential growth phase, medium is removed and replaced with fresh medium (including 1% or 10% serum) containing C75 (35 mM) and simultaneous administration of x-rays (2 Gy). Cells are then incubated for 24 h at 37℃ in 5% CO2. After treatment, cells are counted and seeded for clonogenic survival assay.

• 动物实验： Animal Models: Diet-induced obese mice model Dosages: 20, 15, 10, 15, 15 mg/kg Administration: i.p.

• 参考文献：
  1. Wang X,et al. Bioorg Med Chem. 2009 Mar 1;17(5):1898-904. 2. Cheng X, et al. Org Lett. 2014 Mar 7;16(5):1414-7. 3. Rae C, et al. Adv Radiat Oncol. 2020 Jun 29;5(5):994-1005. 4. Thupari JN, et al. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.932 ml	19.66 ml	39.321 ml
  5 mM	0.786 ml	3.932 ml	7.864 ml
  10 mM	0.393 ml	1.966 ml	3.932 ml
  50 mM	0.079 ml	0.393 ml	0.786 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *