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S84705

Reparixin

源叶(MedMol) 99%
  • 英文名:
  • Reparixin
  • 别名:
  • Reparixin (USAN/INN); RAPARIXIN; reparixin; DF 1681Y;
  • CAS号:
  • 266359-83-5
  • 分子式:
  • C14H21NO3S
  • 分子量:
  • 283.39
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S84705-5mg 99% ¥400.00元 5 - - - EA 加入购物车
源叶(MedMol) S84705-10mg 99% ¥790.00元 3 - - - EA 加入购物车
源叶(MedMol) S84705-25mg 99% ¥1300.00元 1 - - - EA 加入购物车
源叶(MedMol) S84705-100mg 99% ¥3500.00元 2 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
  • 靶点: CXCR1wt:5.6 nM (IC50, in L1.2 cells);CXCR1Ile43Val:80 nM (IC50, in L1.2 cells);CXCR1:1 nM (IC50, in cells);CXCR2:∼100 nM (IC50, in cells);CXCR
  • 体内研究:
    Reparixin is an inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation, has been shown to attenuate inflammatory responses in various injury models. Spontaneously hypertensive rats (SHR) are administered a subcutaneous injection of Reparixin (5 mg/kg) daily for 3 weeks. Reparixin effectively decreases systolic blood pressure and increased the blood flow. Reparixin reduces the levels of IL-1β in the brain after middle cerebral artery occlusion/reperfusion (MCAo) in mice. Bars represent levels of IL-1β (pg/100 mg) measured by ELISA in the brain tissues of mice subjected or not (SHAM) to MCAo and pretreated with vehicle or Reparixin (30 mg/kg, s.c.)
  • 参考文献:
    1. Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002. 2. Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54. 3. Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(1):120-7. 4. Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo). 2013;68(3):391-4. 5. Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. 6. Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. 7. Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201(2):814-820.
  • 溶解性: DMSO  :  ≥  100  mg/mL  (352.87  mM)    H2O  :  <  0.1  mg/mL  (insoluble)
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 3.529 ml 17.644 ml 35.287 ml
    5 mM 0.706 ml 3.529 ml 7.057 ml
    10 mM 0.353 ml 1.764 ml 3.529 ml
    50 mM 0.071 ml 0.353 ml 0.706 ml
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