货号	规格	价格	上海	北京	珠海	南京	武汉
S84762-2mg	99.20%	￥170.00 S84762-2mg ￥170.00 现货	8 8	-	-	-	-
S84762-5mg一口价	99.20%	￥272.00 ￥217.00 S84762-5mg ￥217.00 现货	3 3	-	-	-	-
S84762-10mg一口价	99.20%	￥476.00 ￥380.00 S84762-10mg ￥380.00 现货	4 4	-	-	-	-
S84762-25mg一口价	99.20%	￥850.00 ￥680.00 S84762-25mg ￥680.00 现货	4 4	-	-	-	-
S84762-50mg	99.20%	￥1600.00 S84762-50mg ￥1600.00 现货	5 5	-	-	-	-
S84762-100mg	99.20%	￥2600.00 S84762-100mg ￥2600.00 现货	5 5	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

STAT5-IN-1 是一种有效的选择性 STAT5 抑制剂，其对于STAT5β亚型的IC50值为47 μM

靶点：

STAT5β(Cell-free assay):47 μM;STAT

体外研究：

STAT5-IN-1, the STAT5 phosphorylation specific inhibitor, selectively blocks the STAT5 signaling and decreases the percentage of CD4+CD25+Foxp3+ Tregs after SEC2 stimulation on murine splenocytes

体内研究：

STAT5-IN-1, a STAT5 inhibitor, significantly attenuates atherosclerosis in ApoE-/- mice induced by HFD via decreasing inflammation.

细胞实验：

Cell lines: murine splenocytes Concentrations: 0.47 mM Incubation Time: 3 days Method: Fresh murine splenocytes seeded in 24-well flat-bottom plates are treated with each inhibitor at final concentrations of 10 μM LY294002, 10 mM Trigonelline, 0.47 mM STAT5-IN-1, 50 μM SB431542, and 1 μM SIS3, or treated with 10 μg/mL anti-IL-2 neutralizing antibody, respectively, then cells are stimulated with 104 ng/mL SEC2 for 3 days in a humidified incubator at 37 ℃ with 5% CO2.

动物实验：

Animal Models: ApoE-/- mice Dosages: 10 mg/kg Administration: p.o.

参考文献：

1. Müller J, et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7. 2. Li Y, et al. Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways. Biomed Pharmacother. 2021 Nov;143:112204. 3. Wang X, et al. STAT5 inhibitor attenuates atherosclerosis via inhibition of inflammation: the role of STAT5 in atherosclerosis. Am J Transl Res. 2021;13(3):1422-1431.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.41 ml	17.049 ml	34.097 ml
5 mM	0.682 ml	3.41 ml	6.819 ml
10 mM	0.341 ml	1.705 ml	3.41 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置