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• 产品描述： Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts

• 靶点： Glutaminase C;Glutaminase

• 体外研究：
  Glutaminase C-IN-1 (Compound 968) (10 μM; 14 d) inhibits cellular transformation in NIH 3T3 cells. Glutaminase C-IN-1 (10 μM; 6 d) blocks the signaling activity of a specific target of Dbl. Glutaminase C-IN-1 blocks the transforming activity of human breast cancer cells. Glutaminase C-IN-1 (10 μM) blocks glutaminolysis in transformed cells. Glutaminase C-IN-1 preferentially binds to the monomeric state of Glutaminase C. Cell Viability Assay Cell Line: MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration: 10 μM Incubation Time: 5 h Result: Inhibited cell growth.

• 体内研究：
  Glutaminase C-IN-1 (Compound 968) (200 μg/mouse; i.p.; daily for 12 days) reduces tumor volume in mice. Animal Model: SCID mice with P493 B lymphoma cells Dosage: 200 μg/mouse Administration: Intraperitoneal injection, daily for 12 days Result: Caused a ~50% reduction in the size of the tumors.

• 参考文献：
  1. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19. 2. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.103 ml	10.517 ml	21.034 ml
  5 mM	0.421 ml	2.103 ml	4.207 ml
  10 mM	0.21 ml	1.052 ml	2.103 ml
  50 mM	0.042 ml	0.21 ml	0.421 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *