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• 产品描述： YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness

• 靶点： Aryl Hydrocarbon Receptor;AhR;ArylHydrocarbonReceptor

• 体内研究：
  YL-109 (15 mg/kg; s.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo Animal Model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells Dosage: 15 mg/kg Administration: S.c. every 2 days for 63 days Result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

• 参考文献：
  1. Hiyoshi H, et al. 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP. Sci Rep. 2014 Nov 18;4:7095

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.886 ml	19.432 ml	38.864 ml
  5 mM	0.777 ml	3.886 ml	7.773 ml
  10 mM	0.389 ml	1.943 ml	3.886 ml
  50 mM	0.078 ml	0.389 ml	0.777 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *