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S85100

C29

源叶(MedMol) 98%
  • 英文名:
  • TLR2-IN-C29
  • 别名:
  • CAS号:
  • 363600-92-4
  • 分子式:
  • C16H15NO4
  • 分子量:
  • 285.2946
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S85100-1mg 98% ¥520.00元 1 - - - EA 加入购物车
源叶(MedMol) S85100-2mg 98% ¥800.00元 2 - - - EA 加入购物车
源叶(MedMol) S85100-5mg 98% ¥1440.00元 4 - - - EA 加入购物车
源叶(MedMol) S85100-10mg 98% ¥1920.00元 5 - - - EA 加入购物车
源叶(MedMol) S85100-25mg 98% ¥2400.00元 7 - - - EA 加入购物车
源叶(MedMol) S85100-100mg 98% ¥5120.00元 1 - - - EA 加入购物车
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产品介绍

参考文献(2篇)

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages
  • 靶点: TLR
  • 体外研究:
    C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation
  • 体内研究:
    C29L inhibits TLR2/1-induced inflammation in mice. Mice treated twice with C29L before administration of P3C significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein. C29L has a significant inhibitory effect at the later time point for IL-12 p40
  • 参考文献:
    1. Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. 2. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica[J]. Food & function. 2018 Jul 17;9(7):3930-3943. 3. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease[J]. Journal of Neuroinflammation. 2019, 16(1): 1-14. 4. Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells[J]. Carbohydrate Polymer. 2020, 251: 117088. 5. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism[J]. International Journal of Biological Macromolecules. 2019, 137: 8-19.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 3.505 ml 17.526 ml 35.051 ml
    5 mM 0.701 ml 3.505 ml 7.01 ml
    10 mM 0.351 ml 1.753 ml 3.505 ml
    50 mM 0.07 ml 0.351 ml 0.701 ml
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