S85313 |
Amitifadine (hydrochloride) |
源叶(MedMol) | 98% |
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- 产品描述: Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.
- 靶点: IC50: 12 nM (serotonin), 23 nM (norepinephrine), 96 nM (dopamine);DopamineReceptor;5-HTReceptor;SerotoninTransporter;Norepinephrine
- 体外研究:
Amitifadine (DOV 21,947) is an antidepressant drug. Ki values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectively
- 体内研究:
The 30 mg/kg Amitifadine dose significantly reduces nicotine self-administration. The 5 and 10 mg/kg doses reduce nicotine self-administration during the first 15 min. of the session when the greatest amount of nicotine is self-administered. The 30 mg/kg Amitifadine dose, but not the lower doses cause a significant reduction in locomotor activity averaged over the 1-hour session and reduce food motivated responding. The 10 mg/kg dose causes hypoactivity at the beginning of the session, but 5 mg/kg does not cause any hypoactivity. The effect of chronic Amitifadine treatment (10 mg/kg) over the course of 15 sessions is also determined. Amitifadine causes a significant reduction in nicotine self-administration, which is not seen to diminish over two consecutive weeks of treatment and a week after enforced abstinence. Amitifadine significantly reduces nicotine self-administration. This prompts further research to determine if Amitifadine might be an effective treatment for smoking cessation
- 参考文献:
1. Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a 'triple' reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. 2. Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37.
- 溶解性: Soluble in DMSO、H2O
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 3.78 ml 18.898 ml 37.796 ml 5 mM 0.756 ml 3.78 ml 7.559 ml 10 mM 0.378 ml 1.89 ml 3.78 ml 50 mM 0.076 ml 0.378 ml 0.756 ml
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