货号	规格	价格	上海	北京	武汉	南京	购买数量
S85313-5mg	98%	￥3500.00 S85313-5mg ￥3500.00 2-3天	0 货期：2-3天	-	-	-
S85313-10mg	98%	￥6000.00 S85313-10mg ￥6000.00 2-3天	0 货期：2-3天	-	-	-

产品介绍

Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

产品描述：

Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

靶点：

IC50: 12 nM (serotonin), 23 nM (norepinephrine), 96 nM (dopamine);DopamineReceptor;5-HTReceptor;SerotoninTransporter;Norepinephrine

体外研究：

Amitifadine (DOV 21,947) is an antidepressant drug. Ki values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectively

体内研究：

The 30 mg/kg Amitifadine dose significantly reduces nicotine self-administration. The 5 and 10 mg/kg doses reduce nicotine self-administration during the first 15 min. of the session when the greatest amount of nicotine is self-administered. The 30 mg/kg Amitifadine dose, but not the lower doses cause a significant reduction in locomotor activity averaged over the 1-hour session and reduce food motivated responding. The 10 mg/kg dose causes hypoactivity at the beginning of the session, but 5 mg/kg does not cause any hypoactivity. The effect of chronic Amitifadine treatment (10 mg/kg) over the course of 15 sessions is also determined. Amitifadine causes a significant reduction in nicotine self-administration, which is not seen to diminish over two consecutive weeks of treatment and a week after enforced abstinence. Amitifadine significantly reduces nicotine self-administration. This prompts further research to determine if Amitifadine might be an effective treatment for smoking cessation

参考文献：

1. Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a 'triple' reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. 2. Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.78 ml	18.898 ml	37.796 ml
5 mM	0.756 ml	3.78 ml	7.559 ml
10 mM	0.378 ml	1.89 ml	3.78 ml
50 mM	0.076 ml	0.378 ml	0.756 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

Amitifadine (hydrochloride)