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• 产品描述： Lucanthone is an inhibitor of Apurinic endonuclease-1 (APE-1).

• 靶点： Autophagy;DNA/RNA Synthesis;DNA/RNASynthesis;Autophagy

• 细胞实验： Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content

• 参考文献：
  1. Carew JS,etal.Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.J Biol Chem. 2011 Feb 25;286(8):6602-13. 2. Chowdhury SM,etal.Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme.Nanomedicine. 2015 Jan;11(1):109-18.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.937 ml	14.685 ml	29.37 ml
  5 mM	0.587 ml	2.937 ml	5.874 ml
  10 mM	0.294 ml	1.469 ml	2.937 ml
  50 mM	0.059 ml	0.294 ml	0.587 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *