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• 产品描述： HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway

• 靶点： Smo;Hedgehog/Smoothened;Smo

• 体内研究：
  HhAntag (oral administraion; 75 mg/kg or 100 mg/kg; twice daily; 25 days) results in significant growth delay in HT55 and HT-29 colorectal cell line xenografts models, with average tumour growth inhibitions of 29% and 48%, respectively. Whereas HhAntag had no effect on the growth of DLD-1 xenografts Animal Model: Primary human xenografts in female CD1 nu/nu mice of 6–8 weeks (DLD-1, HT55 and HT-29 cells) Dosage: 75 mg/kg or 100 mg/kg Administration: Oral administraion; twice daily; 25 days Result: Resulted in growth delay of HT55 and HT-29 xenografts, but had no effects on DLD-1 xenografts.

• 参考文献：
  1. Neeraj Mahindroo, et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorg Med Chem. 2010 Jul 1;18(13):4801-11.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.218 ml	11.088 ml	22.177 ml
  5 mM	0.444 ml	2.218 ml	4.435 ml
  10 mM	0.222 ml	1.109 ml	2.218 ml
  50 mM	0.044 ml	0.222 ml	0.444 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *