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• 产品描述： Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

• 靶点： VEGFR1:34 nM (IC50);VEGFR2:13 nM (IC50);VEGFR3:13 nM (IC50);FGFR1:69 nM (IC50);FGFR2:37 nM (IC50);FGFR3:108 nM (IC50);PDGFRα:59 nM (IC50);PDGFRβ:65 nM (IC50);VEGFR;FGFR;PDGFR

• 体内研究：
  Nintedanib (BIBF 1120) (25-100 mg/kg daily p.o.) is highly active in all tumor models, including human tumor xenografts growing in nude mice and a syngeneic rat tumor model. This is evident in the magnetic resonance imaging of tumor perfusion after 3 days, reducing vessel density and vessel integrity after 5 days, and profound growth inhibition[1]. Nintedanib (BIBF 1120) is orally available and displays encouraging efficacy in in vivo tumor models while being well tolerated

• 参考文献：
  1. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782. 2. Suzuki N, et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130. 3. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480.

• 溶解性： Soluble  in  DMSO、Ethanol、H2O

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.539 ml	7.695 ml	15.39 ml
  5 mM	0.308 ml	1.539 ml	3.078 ml
  10 mM	0.154 ml	0.77 ml	1.539 ml
  50 mM	0.031 ml	0.154 ml	0.308 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=15.153] Dongjun Li et al."Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis."Small.2023 Apr;:2300545

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *