• 产品描述： D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1]

• 靶点： IC50: 0.53 μM (tubulin polymerization);MicrotubuleAssociated

• 体内研究：
  D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model. D-64131 has oral bioavailability and is well tolerated at efficacious doses. Animal Model: Outbred nude mice (6-8 weeks), human amelanoic melanoma MEXF 989 tumor xenograft model Dosage: 200 mg/kg, 400 mg/kg Administration: Oral administration, daily, on days 1-5, 8-9, and 15-18 after xenograft Result: Resulted in significant tumor growth inhibition during treatment.

• 参考文献：
  1. Thomas Beckers, et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119. 2. S Mahboobi, et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.98 ml	19.898 ml	39.796 ml
  5 mM	0.796 ml	3.98 ml	7.959 ml
  10 mM	0.398 ml	1.99 ml	3.98 ml
  50 mM	0.08 ml	0.398 ml	0.796 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *