货号	规格	价格	上海	北京	珠海	南京	武汉
S86478-2mg	99.80%	￥220.00 S86478-2mg ￥220.00 现货	5 5	-	-	-	-
S86478-5mg	99.80%	￥260.00 S86478-5mg ￥260.00 现货	6 6	-	-	-	-
S86478-10mg	99.80%	￥410.00 S86478-10mg ￥410.00 现货	7 7	-	-	-	-
S86478-25mg	99.80%	￥820.00 S86478-25mg ￥820.00 现货	6 6	-	-	-	-
S86478-50mg	99.80%	￥1200.00 S86478-50mg ￥1200.00 现货	5 5	-	-	-	-
S86478-100mg	99.80%	￥1870.00 S86478-100mg ￥1870.00 现货	5 5	-	-	-	-

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产品描述：

KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research

靶点：

CFTR;Autophagy

体外研究：

Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics

体内研究：

In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice.

参考文献：

1. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. 2. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.368 ml	11.839 ml	23.678 ml
5 mM	0.474 ml	2.368 ml	4.736 ml
10 mM	0.237 ml	1.184 ml	2.368 ml
50 mM	0.047 ml	0.237 ml	0.474 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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