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S86478

KM11060

源叶(MedMol) 98%
  • 英文名:
  • KM11060
  • 别名:
  • CAS号:
  • 774549-97-2
  • 分子式:
  • C19H17Cl2N3O2S
  • 分子量:
  • 422.3282
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S86478-2mg 98% ¥221.00元 5 - - - EA 加入购物车
源叶(MedMol) S86478-5mg 98% ¥285.00元 6 - - - EA 加入购物车
源叶(MedMol) S86478-10mg 98% ¥495.00元 7 - - - EA 加入购物车
源叶(MedMol) S86478-25mg 98% ¥990.00元 6 - - - EA 加入购物车
源叶(MedMol) S86478-50mg 98% ¥1830.00元 5 - - - EA 加入购物车
源叶(MedMol) S86478-100mg 98% ¥2900.00元 5 - - - EA 加入购物车
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  • 产品描述: KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research
  • 靶点: CFTR;Autophagy
  • 体外研究:
    Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics
  • 体内研究:
    In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice.
  • 参考文献:
    1. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. 2. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.
  • 溶解性: soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.368 ml 11.839 ml 23.678 ml
    5 mM 0.474 ml 2.368 ml 4.736 ml
    10 mM 0.237 ml 1.184 ml 2.368 ml
    50 mM 0.047 ml 0.237 ml 0.474 ml
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