- 产品描述: DFMTI can completely block the rmGlu1 L757V glutamate response
- 体外研究:
DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.
- 体内研究:
DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
- 参考文献:
1. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.
- 溶解性: 10 mM in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.715 ml 13.573 ml 27.146 ml 5 mM 0.543 ml 2.715 ml 5.429 ml 10 mM 0.271 ml 1.357 ml 2.715 ml 50 mM 0.054 ml 0.271 ml 0.543 ml
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输入产品批号:
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)