• 提示：详情请下载说明书。

• 产品描述： PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.

• 靶点： IC50: 0.3 nM;ProstaglandinReceptor

• 体外研究：
  Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion

• 参考文献：
  1. Lim, Sungtaek, et al. 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS. WO2006044732A2. 2. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.172 ml	10.861 ml	21.722 ml
  5 mM	0.434 ml	2.172 ml	4.344 ml
  10 mM	0.217 ml	1.086 ml	2.172 ml
  50 mM	0.043 ml	0.217 ml	0.434 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *