S87145 |
ML348 |
源叶(MedMol) | 99% |
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- 产品描述: ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2
- 靶点: IC 50: 210 nM (LYPLA1);Phospholipase
- 体外研究:
ML348 (5 µM; 3 hours ) selectively inhibits LYPLA1 in cultured cells. Cell Viability Assay Cell Line: HEK293T cells, murine T-cells Concentration: 5 µM Incubation Time: 3 hours Result: Show potent, selective inhibition of LYPLA1.
- 体内研究:
ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice. Animal Model: C57BL6 male mice (3-4 months) Dosage: 50 mg/kg Administration: Intraperitoneal injection; 3 hours Result: Potent and selective inhibited LYPLA1 enzymes in heart, kidney and lung in vivo.
- 参考文献:
1. Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). National Center for Biotechnology Information (US); 2010- 2013 Apr 08.
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.405 ml 12.025 ml 24.05 ml 5 mM 0.481 ml 2.405 ml 4.81 ml 10 mM 0.241 ml 1.203 ml 2.405 ml 50 mM 0.048 ml 0.241 ml 0.481 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)