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• 产品描述： Morinidazole shows antibacterial activity and can be used in studies about bacterial infections research such as appendicitis and pelvic inflammatory disease caused by anaerobic bacteria.

• 靶点： Antibacterial

• 体外研究：
  Morinidazole shows antibacterial activity against Trichomonas vaginalis and Entamoeba histolytica with MICs of 2 and 3 μg/mL

• 体内研究：
  Morinidazole (20 and 25 mg/kg; p.o.) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo[2]. In the renal failure model in SD rats, Morinidazole (50 mg/kg; i.v.) shows a higher concentration in the liver, plasma, and kidney than lung, spleen, and heart

• 参考文献：
  1. Zhong K, et al. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearanceof the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61. 2. Lu Aifeng, et al. Application of α-(morpholine-1-yl)methyl-2-methyl-nitroimidazole-1-ethanol as anti-trichomonal agent and amebacide: China, CN1981764[P]. 2007-06-20. 3. Kong F, et al. Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Drug Metab Dispos. 2017 Jun;45(6):593-603.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.7 ml	18.499 ml	36.998 ml
  5 mM	0.74 ml	3.7 ml	7.4 ml
  10 mM	0.37 ml	1.85 ml	3.7 ml
  50 mM	0.074 ml	0.37 ml	0.74 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *